Search scope:
排序: Display mode:
Metformin and metabolic diseases: a focus on hepatic aspects
Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 173-186 doi: 10.1007/s11684-015-0384-0
Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses hepatic glucose production (HGP), serving as the main mechanism by which metformin improves hyperglycemia of T2D. Biochemically, metformin suppresses gluconeogenesis and stimulates glycolysis. Metformin also inhibits glycogenolysis, which is a pathway that critically contributes to elevated HGP. While generating beneficial effects on hyperglycemia, metformin also improves insulin resistance and corrects dyslipidemia in patients with T2D. These beneficial effects of metformin implicate a role for metformin in managing non-alcoholic fatty liver disease. As supported by the results from both human and animal studies, metformin improves hepatic steatosis and suppresses liver inflammation. Mechanistically, the beneficial effects of metformin on hepatic aspects are mediated through both adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. In addition, metformin is generally safe and may also benefit patients with other chronic liver diseases.
Keywords: metformin diabetes hepatic steatosis inflammatory response insulin resistance
C. RENNO, A. PERONE
Frontiers in Energy 2021, Volume 15, Issue 2, Pages 384-395 doi: 10.1007/s11708-020-0717-9
Keywords: CPV system point-focus experimental model energy and economic analysis
Review of aeroelasticity for wind turbine: Current status, research focus and future perspectives
Pinting ZHANG, Shuhong HUANG
Frontiers in Energy 2011, Volume 5, Issue 4, Pages 419-434 doi: 10.1007/s11708-011-0166-6
Keywords: wind turbine aeroelasticity aeroelastic code
Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 6, doi: 10.1007/s11783-023-1666-4
● A global snapshot of plastic waste generation and disposal is analysed.
Keywords: Plastic waste Farmlands Terrestrial ecosystem Marine life
Xiliang ZHANG, Zhiying CUI, Jianhan ZHANG, Fengwu BAI, Zhifeng WANG
Frontiers in Energy 2019, Volume 13, Issue 3, Pages 590-596 doi: 10.1007/s11708-018-0602-y
Keywords: secondary parabolic trough solar concentrator ray tracing method linear focus concentration ratio optical
Frontiers of Engineering Management 2022, Volume 9, Issue 2, Pages 177-195 doi: 10.1007/s42524-021-0184-y
Keywords: blockchain construction project smart contract smart payment payment dispute
Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)
Frontiers of Medicine doi: 10.1007/s11684-023-1037-3
Keywords: COVID-19 antiviral drugs mindeudesivir
Ping Sheng
Engineering 2021, Volume 7, Issue 5, Pages 552-553 doi: 10.1016/j.eng.2021.02.003
Uwe LUDEWIG, Lixing YUAN, Günter NEUMANN
Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 4, Pages 357-365 doi: 10.15302/J-FASE-2019275
Phosphorus (P) is essential for life and for efficient crop production, but global P use with limited recycling is inefficient in several sectors, including agronomy. Unfortunately, plant physiologists, agronomists, farmers and end users employ different measures for P use efficiency (PUE), which often masks their values at different scales. The term P use effectiveness, which also considers energetic and sustainability measures in addition to P balances, is also a valuable concept. Major physiological and genetic factors for plant P uptake and utilization have been identified, but there has been limited success in genetically improving PUE of modern crop cultivars. In maize, studies on root architectural and morphological traits appear promising. Rhizosphere processes assist in mobilizing and capturing sparingly soluble phosphate from rock phosphate. Combinations of phosphate-solubilizing microorganisms with ammonium-based nitrogen fertilizer, as well as strategies of fertilizer placement near the roots of target crops, can moderately enhance PUE. The desired concentration of P in the products differs, depending on the final use of the crop products as feed, food or for energy conversion, which should be considered during crop production.
Keywords: acquisition efficiency plant growth promoting rhizobacteria phosphate use efficiency utilization efficiency
FOR USE IN AGROECOSYSTEM IMPROVEMENT IN SEMI-ARID AREAS WITH A FOCUS ON CENTRAL ANATOLIA, TURKEY
Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4, Pages 568-582 doi: 10.15302/J-FASE -2019270
Keywords: actinorrhizal trees / agroforestry / climate change / ecosystem restoration
Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins
Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong
Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 231-241 doi: 10.1007/s11684-013-0253-7
Keywords: liver cancer epigenetics histone modifications polycomb group proteins enhancer of zeste homolog 2 (EZH2)
Hydrogen Power Focus Shifts from Cars to Heavy Vehicles
Chris Palmer
Engineering 2020, Volume 6, Issue 12, Pages 1333-1335 doi: 10.1016/j.eng.2020.10.006
Lei Zheng, Xingbao Gao, Wei Wang, Zifu Li, Lingling Zhang, Shikun Cheng
Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 1, doi: 10.1007/s11783-019-1184-6
Keywords: MSWI fly ash Cementing efficiency Health risk assessment of heavy metal Sand replacement Cement replacement
Zhang Jun and Lu Bingheng
Strategic Study of CAE 2017, Volume 19, Issue 3, Pages 136-141 doi: 10.15302/J-SSCAE-2017.03.019
The continual development of high-end manufacturing equipment is essential for the development of the high-end equipment manufacturing industry. By examining the development trends of aeronautic equipment, aerospace equipment, rail transportation equipment, ocean engineering equipment and intelligent manufacturing equipment during the 13th Five-Year Plan, these authors analyze the new demands and future priorities of high-end manufacturing equipment. Starting from the current situation of manufacturing equipment enterprises in China, this paper puts forward suggestions to promote the sound development of the high-end equipment manufacturing industry.
Keywords: high-end equipment manufacturing industry high-end manufacturing equipment machine tool basic manufacturing equipment
Multi-focus image fusion based on fractional-order derivative and intuitionistic fuzzy sets Research Articles
Xue-feng Zhang, Hui Yan, Hao He,zhangxuefeng@mail.neu.edu.cn
Frontiers of Information Technology & Electronic Engineering 2020, Volume 21, Issue 6, Pages 809-962 doi: 10.1631/FITEE.1900737
Keywords: 像融合;分数阶导数;直觉模糊集;多聚焦图像
Title Author Date Type Operation
Metformin and metabolic diseases: a focus on hepatic aspects
Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu
Journal Article
Energy and economic analysis of a point-focus concentrating photovoltaic system when its installation
C. RENNO, A. PERONE
Journal Article
Review of aeroelasticity for wind turbine: Current status, research focus and future perspectives
Pinting ZHANG, Shuhong HUANG
Journal Article
Current scenario and challenges of plastic pollution in Bangladesh: a focus on farmlands and terrestrial
Journal Article
Optical performance analysis of an innovative linear focus secondary trough solar concentrating system
Xiliang ZHANG, Zhiying CUI, Jianhan ZHANG, Fengwu BAI, Zhifeng WANG
Journal Article
Blockchain-based smart contract for smart payment in construction: A focus on the payment freezing and
Journal Article
Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)
Journal Article
Improving the efficiency and effectiveness of global phosphorus use: focus on root and rhizosphere levels
Uwe LUDEWIG, Lixing YUAN, Günter NEUMANN
Journal Article
FOR USE IN AGROECOSYSTEM IMPROVEMENT IN SEMI-ARID AREAS WITH A FOCUS ON CENTRAL ANATOLIA, TURKEY
Journal Article
Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins
Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong
Journal Article
Utilization of MSWI fly ash as partial cement or sand substitute with focus on cementing efficiency and
Lei Zheng, Xingbao Gao, Wei Wang, Zifu Li, Lingling Zhang, Shikun Cheng
Journal Article
Requirement Analysis of High-End Manufacturing Equipment with a Focus on the High-End Equipment Manufacturing
Zhang Jun and Lu Bingheng
Journal Article